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ABSTRACT ABSTRACT: The respiratory responses to theophylline during normoxia and hypoxia were determined in 13 unanesthetized fetal sheep. Theophylline (plasma levels ∼ 111 μmol/L) increased

the incidence of fetal breathing movements measured over 120 min from 37.7 ± 4.8% to 61.1 ± 5.7% (SEM) in normoxic fetuses. In isocapnic hypoxia (arterial O2 tension ∼ 1.86 kPa),

theophylline increased the incidence from 20.0 ± 6.3 to 52.0 ± 6.1%. Theophylline also resulted in an increase in the slope of inspiration during both normoxia and hypoxia. We conclude that

adenosine modulates fetal respiratory drive during normoxia and hypoxia. SIMILAR CONTENT BEING VIEWED BY OTHERS CAFFEINE IS A RESPIRATORY STIMULANT WITHOUT EFFECT ON SLEEP IN THE SHORT-TERM

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INFORMATION AUTHORS AND AFFILIATIONS * Department of Obstetrics and Gynecology. Oregon Health Sciences University, Portland, 97201, Oregon John M Bissonnette, Roger A Hohimer, Conrad R Chao,

 Sharon J Knopp & Neil F Notoroberto Authors * John M Bissonnette View author publications You can also search for this author inPubMed Google Scholar * Roger A Hohimer View author

publications You can also search for this author inPubMed Google Scholar * Conrad R Chao View author publications You can also search for this author inPubMed Google Scholar * Sharon J Knopp

View author publications You can also search for this author inPubMed Google Scholar * Neil F Notoroberto View author publications You can also search for this author inPubMed Google

Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bissonnette, J., Hohimer, R., Chao, C. _et al._ Theophylline Stimulates Fetal Breathing Movements

during Hypoxia. _Pediatr Res_ 28, 83–86 (1990). https://doi.org/10.1203/00006450-199008000-00002 Download citation * Received: 14 November 1989 * Accepted: 23 March 1990 * Issue Date: 01

August 1990 * DOI: https://doi.org/10.1203/00006450-199008000-00002 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

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