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ABSTRACT OBJECTIVE Newborns with trisomy 21 (T21) often require NICU hospitalization. Oxygen desaturations are frequently observed in these infants, even in the absence of congenital heart

defects (CHD). We hypothesized that NICU patients with T21 have more hypoxemia than those without T21. DESIGN All infants with T21 without significant CHD discharged home from the NICU

between 2009 and 2018 were included (_n_ = 23). Controls were matched 20:1 for gestational age and length of stay. We compared daily severe hypoxemia events (SpO2 < 80% for ≥10 s) for the

whole NICU stay and the pre-discharge week. RESULTS Infants with T21 showed significantly more daily hypoxemia events during their entire NICU stay (median 10 versus 7, _p_ = 0.0064), and

more so in their final week (13 versus 7, _p_ = 0.0008). CONCLUSION NICU patients with T21 without CHD experience more severe hypoxemia events than controls, particularly in the week before

discharge. Whether this hypoxemia predicts or contributes to adverse outcomes is unknown. Access through your institution Buy or subscribe This is a preview of subscription content, access

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Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS MORTALITY AND MORBIDITY OF INFANTS WITH TRISOMY 21,

WEIGHING 1500 GRAMS OR LESS, IN JAPAN Article 05 July 2022 PREGNANCY OUTCOMES AMONG PATIENTS WITH COMPLEX CONGENITAL HEART DISEASE Article Open access 17 September 2024 CRITICAL CONGENITAL

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in down syndrome. Mol Med. 2020;26:102. Article  Google Scholar  Download references FUNDING NICHD R01HD072071. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine,

Division of Cardiology, University of Virginia, Charlottesville, VA, USA Katy N. Krahn & Amanda M. Zimmet * Department of Pediatrics, Division of Neonatology, University of Virginia,

Charlottesville, VA, USA V. Peter Nagraj & Karen D. Fairchild * Department of Pediatrics, Division of Cardiology, University of Virginia, Charlottesville, VA, USA Michael A. McCulloch

Authors * Katy N. Krahn View author publications You can also search for this author inPubMed Google Scholar * V. Peter Nagraj View author publications You can also search for this author

inPubMed Google Scholar * Michael A. McCulloch View author publications You can also search for this author inPubMed Google Scholar * Amanda M. Zimmet View author publications You can also

search for this author inPubMed Google Scholar * Karen D. Fairchild View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence

to Karen D. Fairchild. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors declare no competing interests. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with

regard to jurisdictional claims in published maps and institutional affiliations. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Krahn, K.N., Nagraj,

V.P., McCulloch, M.A. _et al._ Hypoxemia in infants with trisomy 21 in the neonatal intensive care unit. _J Perinatol_ 41, 1448–1453 (2021). https://doi.org/10.1038/s41372-021-01105-7

Download citation * Received: 26 January 2021 * Revised: 26 April 2021 * Accepted: 10 May 2021 * Published: 25 May 2021 * Issue Date: June 2021 * DOI:

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