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Access through your institution Buy or subscribe Jin et al. demonstrate that a recently defined T-cell population, known as virtual memory T cells, accumulate with human immunodeficiency

virus (HIV), are inversely correlated with latent viral load and may be uniquely well suited to eliminate latently infected cells during chronic infections. Infection with HIV presents many

challenges to the immune system, but viral reservoirs are one of the most intractable. Treatment of HIV has been revolutionized by antiretroviral therapy (ART), which effectively ablates

viral replication in patients. Unfortunately, a real cure remains elusive, as HIV will persist in latently infected cells. The identification of immune mechanisms that can reduce this latent

reservoir may improve treatment and progress cure strategies for HIV. In this issue, Jin et al. demonstrate that the activity of an unconventional immune cell, the virtual memory T (TVM)

cell, may play a role.1 This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 digital

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Scholar  * Webb, G. M. et al. _Blood Adv._ 2, 76–84 (2018). Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS K.M.Q. is supported by an RMIT University Vice-Chancellor’s

Research Fellowship and the Rebecca L. Cooper Foundation. T.H. is supported by the Monash Graduate Scholarship and Monash International Postgraduate Research Scholarship. AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, 3083, Australia Kylie M. Quinn * Monash Biomedicine Discovery Institute, Monash

University, Clayton, VIC, 3800, Australia Kylie M. Quinn & Tabinda Hussain * Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia Kylie M.

Quinn & Tabinda Hussain Authors * Kylie M. Quinn View author publications You can also search for this author inPubMed Google Scholar * Tabinda Hussain View author publications You can

also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Kylie M. Quinn. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests.

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Quinn, K.M., Hussain, T. Bystanders or real players: virtual memory T cells keep chronic infections in

check. _Cell Mol Immunol_ 17, 797–798 (2020). https://doi.org/10.1038/s41423-020-0469-9 Download citation * Received: 28 April 2020 * Accepted: 29 April 2020 * Published: 25 May 2020 * Issue

Date: August 2020 * DOI: https://doi.org/10.1038/s41423-020-0469-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

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