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Extramitochondrial coenzyme Q (CoQ) can function as a potent anti-ferroptosis radical trapper. However, it is largely unknown how CoQ is transported from mitochondria to the plasma membrane.

A study now suggests that PARL-mediated STARD7 processing is responsible for the cellular distribution of CoQ. Access through your institution Buy or subscribe This is a preview of

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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Stefely, J. A. & Pagliarini, D. J. _Trends Biochem. Sci._ 42, 824–843 (2017).

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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Deguang Liang & Xuejun Jiang Authors * Deguang Liang View

author publications You can also search for this author inPubMed Google Scholar * Xuejun Jiang View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHOR Correspondence to Xuejun Jiang. ETHICS DECLARATIONS COMPETING INTERESTS D.L. is an inventor of a patent relevant to autophagy. X.J. is an inventor of patents relevant to

cell death and autophagy. He is also a consultant and equity holder of Exarta Therapeutics and Lime Therapeutics. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Liang, D., Jiang, X. START smuggling CoQ to fight ferroptosis. _Nat Cell Biol_ 25, 207–208 (2023). https://doi.org/10.1038/s41556-022-01044-1 Download citation * Published: 19

January 2023 * Issue Date: February 2023 * DOI: https://doi.org/10.1038/s41556-022-01044-1 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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