Pitching ursodeoxycholic acid in intrahepatic cholestasis of pregnancy versus placebo

Pitching ursodeoxycholic acid in intrahepatic cholestasis of pregnancy versus placebo


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Access through your institution Buy or subscribe Treatment with ursodeoxycholic acid (UCDA) did not reduce perinatal outcomes in women with intrahepatic cholestasis of pregnancy, according


to results in a new large, placebo-controlled randomized trial (PITCHES). 605 women were enrolled in the study from across 33 hospital maternity units in England and Wales and were randomly


allocated to receive either UCDA (_n_ = 305) or placebo (_n_ = 300). The primary outcome, which included perinatal death, preterm delivery or neonatal unit admission for at least 4 h, was


similar between the two treatment groups, 23% in the UCDA group versus 27% in the placebo group (adjusted risk ratio of 0.85; 95% CI 0.62–1.15). As UCDA does not seem to have any substantial


clinical benefit in intrahepatic cholestasis of pregnancy, the authors recommend reconsidering the routine use of UCDA for this condition. This is a preview of subscription content, access


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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Chappell, L. C. et al. Ursodeoxycholic acid versus placebo in women with intrahepatic


cholestasis of pregnancy (PITCHES): a randomised controlled trial. _Lancet_ https://doi.org/10.1016/S0140-6736(19)31270-X (2019) Article  PubMed  PubMed Central  Google Scholar  Download


references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/ Katrina Ray Authors * Katrina Ray View author


publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Katrina Ray. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS


ARTICLE CITE THIS ARTICLE Ray, K. PITCHing ursodeoxycholic acid in intrahepatic cholestasis of pregnancy versus placebo. _Nat Rev Gastroenterol Hepatol_ 16, 582 (2019).


https://doi.org/10.1038/s41575-019-0201-3 Download citation * Published: 20 August 2019 * Issue Date: October 2019 * DOI: https://doi.org/10.1038/s41575-019-0201-3 SHARE THIS ARTICLE Anyone


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