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Access through your institution Buy or subscribe In diabetic kidney disease (DKD), the link between diabetes and damage to podocytes is unclear. Mitochondrial dysfunction caused by lipid

accumulation in podocytes might increase their susceptibility to injury, as reported by Alessia Fornoni, Sandra Merscher, Flavia Fontanesi and colleagues. “We had previously shown that

glomerular expression of phospholipid-transporting ATPase ABCA1 was lower in patients with DKD than in healthy controls, and that reducing _Abca1_ expression in mouse podocytes caused

cholesterol accumulation,” explains Merscher. To assess the potential contribution of ABCA1 to kidney disease in the context of diabetes, the researchers induced a podocyte-specific deletion

of _Abca1_ in diabetic _ob_/_ob_ mice. The loss of _Abca1_ was accompanied by an increase in albuminuria and mesangial expansion, a reduction in the number of podocytes and podocyte foot

processes, and increased cholesterol ester in the kidney. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature

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ARTICLE * Ducasa, G. M. et al. ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes. _J. Clin. Invest._ https://doi.org/10.1172/JCI125316

(2019) Article  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Nephrology http://www.nature.com/nrneph Monica Wang Authors * Monica

Wang View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Monica Wang. RIGHTS AND PERMISSIONS Reprints and permissions

ABOUT THIS ARTICLE CITE THIS ARTICLE Wang, M. Lipids mediate podocyte damage. _Nat Rev Nephrol_ 15, 594 (2019). https://doi.org/10.1038/s41581-019-0196-6 Download citation * Published: 09

August 2019 * Issue Date: October 2019 * DOI: https://doi.org/10.1038/s41581-019-0196-6 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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