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Access through your institution Buy or subscribe The number, morphology and molecular profiles of microglia vary across the brain and are influenced by the microenvironment; however, the

local signals that regulate these differences are poorly understood. Stogsdill, Kim et al. now show that, in mice, the identities of cortical microglia are shaped by nearby pyramidal neuron

subtypes, and begin to dissect the molecular basis of these neuron–microglia interactions. To determine whether these differences in microglial abundance are accompanied by layer-specific

differences in microglial type, the authors performed single-cell RNA-sequencing (scRNA-seq) on microglia from different cortical layers. Across the cortex, they identified eight

transcriptomic microglial ‘states’, several of which were enriched in certain cortical layers. In particular, microglia with a transcriptional profile that the authors refer to as

‘homeostatic 1’ were found in greater numbers in the upper layers (L1–L4), whereas those with another profile, ‘homeostatic 2’, were enriched in L5 and L6. This is a preview of subscription

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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in

* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Stogsdill, J. A. et al. Pyramidal neuron subtype diversity governs

microglia states in the neocortex. _Nature_ https://doi.org/10.1038/s41586-022-05056-7 (2022) Article  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS

* Nature Reviews Neuroscience http://www.nature.com/nrn/ Katherine Whalley Authors * Katherine Whalley View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHOR Correspondence to Katherine Whalley. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Whalley, K. Neuronal neighbours tune microglial

identity. _Nat Rev Neurosci_ 23, 582–583 (2022). https://doi.org/10.1038/s41583-022-00632-2 Download citation * Published: 30 August 2022 * Issue Date: October 2022 * DOI:

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