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ABSTRACT Improving diabetes self-management (DSM) is facing real-world challenges among people with type 2 diabetes mellitus (T2DM) who have a low education level in resource-limited areas.

This study aimed to investigate whether diabetes knowledge could predict glycemic levels in people with T2DM in rural China. This analytical cross-sectional study recruited 321 people with

T2DM from eight villages by purposive sampling at baseline. After 10 months, 206 patients completed the follow-up survey and HbA1c tests, with a response rate of 64.17% (206/321). Multiple

regression analysis was employed to explore the correlation between diabetes knowledge and HbA1c levels. The patient's diabetes knowledge was significantly negatively correlated with

HbA1c levels before and after controlling for covariates in both hierarchical multiple regression and multiple logistic regression (_p_ < 0.01). In addition, other influencing factors,

including sex, age, marital status, employment status, income, and HbA1c levels at baseline, were also identified. Diabetes knowledge could predict HbA1c levels significantly among patients

with low education levels in rural China. Therefore, interventions on improving diabetes knowledge need to be strengthened for patients in rural China so that they can improve their health

outcomes and reduce the disease burden. SIMILAR CONTENT BEING VIEWED BY OTHERS POOR SELF-CARE PRACTICES AND CONTRIBUTING FACTORS AMONG ADULTS WITH TYPE 2 DIABETES IN ADAMA, ETHIOPIA Article

Open access 13 June 2024 MAGNITUDE AND PREDICTORS OF POOR GLYCEMIC CONTROL IN PATIENTS WITH DIABETES AT JIMMA MEDICAL CENTER, ETHIOPIA Article Open access 24 September 2023 LIFESTYLE

MODIFICATION AND MEDICATION USE AMONG DIABETES MELLITUS PATIENTS ATTENDING JIMMA UNIVERSITY MEDICAL CENTER, JIMMA ZONE, SOUTH WEST ETHIOPIA Article Open access 27 March 2023 INTRODUCTION The

prevalence of type 2 diabetes mellitus (T2DM) has sharply increased in the past four decades1. Diabetes and its complications not only seriously affect patients’ health but also bring huge

economic burdens to patients, their families, and society. In 2019, China’s medical expenditures related to diabetes reached $109 billion, ranking second in the world2. To prevent and

control diabetes, numerous studies were conducted and confirmed that lifestyle factors could influence patients’ health outcomes3,4,5. Furthermore, several studies, which were conducted in

China, Finland, and America, found that lifestyle interventions, including diet and exercise, can postpone the onset of T2DM, reduce the incidence of diabetes complications, and ultimately

increase the life expectancy of people with T2DM6,7,8,9,10,11. To apply existing and extensive evidence to manage diabetes in primary care, the International Diabetes Federation (IDF)

emphasized that the cornerstone of T2DM management is to improve diabetes self-management (DSM) ability, including diet, medication adherence, physical activity, and healthy body weight and

has produced a series of guidelines on diabetes management, prevention, and care12,13. China has the largest number of people with diabetes1 and thus may face the considerable challenge of

chronic complications in the future. The government has already paid much attention to managing diabetes and enacted the _policy of equalization of basic public health services_ in 200914.

In rural China, people with T2DM are targeted as the key population for chronic disease management and the specific measures include regular quarterly follow-ups, free fasting blood glucose

(FBG) tests, an annual comprehensive health examination, health education, and different medical prescriptions for people with T2DM15. Although the policy has been implemented for almost 12 

years, the challenge related to diabetes prevention and control remains large and serious16,17. A recent study estimated that only 49.2% of treated patients achieved successful glycemic

control in China (HbA1c levels ≤ 7.0%)18. Another study showed that patients’ DSM behavior scores were at a lower-middle level in a suburban hospital in Beijing19. Similarly, a study

conducted in Shandong Province found that, compared with patients from urban areas, patients from rural areas had poorer DSM behaviors20. Patients in rural China are facing greater

difficulties and challenges than those in urban areas because of their lower education levels21 and an unbalanced distribution of high-quality medical resources22. Therefore, improving the

DSM of people with T2DM through educational interventions in rural China should be a top priority now and in the future23. HbA1c, which reflects average plasma glucose over 2 to 3 months

preceding the test, has been not only considered as a biomarker for the presence and severity of hyperglycemia, implying diabetes or pre-diabetes24, but also considered as a risk factor

marker for diabetes-related complications25 in the process of diabetes treatment and management. Serval studies indicated that high HbA1c variability is not only associated with

cardiovascular complications of T2DM26,27 but also associated with increased risk of all-cause and cardiovascular mortality25. Therefore, HbA1c was used as a biochemical marker of glucose

regulation in people with T2DM28, and it was also an outcome variable in the diabetes prevention intervention program29. Similarly, HbA1c will also be an important outcome variable in our

future intervention studies, aiming to reflect glycemic management in patients with diabetes. Before the intervention, the relationship between diabetes knowledge and HbA1c levels should be

cleared. Although there have been a few studies investigating the effects of the policy30,31, which indicated changes in diabetes knowledge, medication compliance, DSM, and HbA1c levels,

little attention has been given to further exploring the association between diabetes knowledge and HbA1c levels in patients in rural China. Besides, these studies have used cross-sectional

data32,33,34, which cannot do the causal inference. Therefore, this analytical cross-sectional study aimed to investigate whether diabetes knowledge could predict the HbA1c levels of people

with T2DM who have a low education level in rural China based on tracking data. MATERIALS AND METHODS PARTICIPANTS The baseline survey was conducted from January 4 to January 17, 2020, in

eight villages of three towns in DaFeng District, Jiangsu Province. Participants who were diagnosed with T2DM based on their electronic health records in each village clinic were involved in

this study. Inclusion criteria: (1) a diagnosis of T2DM from a hospital at a secondary level and above, based on _Guidelines for the Prevention and Treatment of Type 2 Diabetes in China_35;

(2) 18 years old and above; and (3) continuous residence for more than one year. Exclusion criteria included the inability to participate due to physical/mental disabilities or cognitive

impairment. Eventually, a sample of 321 participants was recruited into the study. SAMPLING In China, there is a five-tier administrative system, including provinces, cities,

counties/districts, towns, and villages/communities36. Purposive sampling was employed in this study: (1) Dafeng District was chosen as the site because it is highly representative from the

perspective of economic development level and is a National Demonstration Area for comprehensive prevention and control of chronic diseases37. (2) Three towns, including W town, X town, and

D town, were selected based on the results of the performance assessment conducted by the local health bureau. (3) Two villages from W town, four villages from X town, and one village from D

town were selected based on the population size of the town. (4) All people with T2DM who registered in the village clinic and met the inclusion criteria were interviewed face-to-face by

trained interviewers. Since there were no related studies on the effect size between diabetes knowledge and HbA1c, we chose a small effect size (0.15)38 to achieve a maximum sample size. A

priori G*power 3.139 calculations revealed a minimum sample size of 117 participants within a multiple regression analysis with 5 predictors to detect a small effect size, using α = 0.05,

power (1-β) = 0.90, and effect size = 0.15. Taking into account a 20% loss-to-follow-up rate, the final total sample size was 141 participants. PROCEDURE FOR FIELD SURVEY The patients who

volunteered to participate in the study were invited to village clinics, and four well-educated graduate students conducted the self-report questionnaire. The village doctors at village

clinics were responsible for the HbA1c test. Considering that most participants, with low levels of education, cannot speak Mandarin, four trained volunteers from a local voluntary

organization were invited to solve dialect barriers. Three hundred and twenty-one participants completed the baseline survey. Ten months later, 206 participants completed the follow-up

investigation and received HbA1c tests, and the attrition rate was 35.83% (115/321). There were no significant differences between the follow-up samples and loss to follow-up samples sample

in terms of age (t = −0.504, _p_ = 0.630), HbA1c level at baseline (t = 0.520, _p_ = 0.603), and diabetes knowledge (t = −0.512, _p_ = 0.609), except that the higher proportion of females

was found in respondents (χ2 = 10.137, _p_ = 0.001). Therefore, the loss to follow-up did not affect the stability of the relationship between diabetes knowledge and HbA1c levels.

MEASUREMENTS DEMOGRAPHIC INFORMATION AND CLINICAL CHARACTERISTICS The information, including age, sex, education level, marital status, employment status, and annual household income, was

collected during the baseline survey. Clinical characteristics, including a family history of diabetes, body mass index (BMI), duration of diabetes, hypoglycemia, and diabetes complications,

including hypertension, cardiac disease, diabetic nephropathy, diabetic retinopathy, diabetic peripheral angiopathy, and others, were obtained from the electronic health record system at

township health centers. DIABETES KNOWLEDGE Diabetes knowledge was assessed by the modified 20-item Diabetes Knowledge scale at baseline, which combined the original version of Diabetes

Knowledge scale (DKN)40 with the Chinese version of DKN scale41. Taking into account the literacy level and lifestyle of the participants, we fine-tuned the scale. The process can be found

in the Appendix. The final version of the DKN scale consisted of 17 single-choice items and 3 multiple-choice items. Each item is assigned a score of one for a correct answer and 0 for an

incorrect or unknown response. A higher score suggested a higher level of diabetes knowledge. Cronbach’s alpha of the modified 20-item DKN scale in this sample was 0.73. HBA1C TEST HbA1c

level reflects the average blood glucose concentrations for the preceding 2–3 months in patients42,43. In this study, HbA1c levels were tested, at baseline (T1) and 10-month (T2) follow-up

surveys, by using the portable HbA1c meter and the Diagnosis Kit for Human Glycosylated Hemoglobin (Botangping in Chinese). MEDICATION ADHERENCE Medication adherence was measured at T2 using

a self-designed questionnaire based on a thesis about medication adherence in Chinese people with heart failure44, which includes eight items concerning the situation of forgetting to take

medicine (four items), unauthorized withdrawal of taking medicine (two items), and perceived difficulty in taking prescribed medication (one item). Each item was designed with a five-point

scale ranging from 1 to 5, and the total score was 40. If a participant’s score was equal to 40, it was defined as “medication adherence”; otherwise, it was defined as “medication

nonadherence”. In this study, Cronbach’s alpha of the self-designed questionnaire was 0.93. DIABETES SELF-MANAGEMENT An adapted version of the Diabetes Self-care Activities (SDSCA) measure,

which consists of items covering diet, exercise, blood sugar testing, foot care, and smoking, was used to assess the level of DSM in this study45. After the pilot study, some changes were

made as follows: (1) The term “checking your foot” was removed because participants could not understand and communicate the true meaning. (2) Several specific food names were supplemented

behind the word “high-fat food” to ensure participants’ better understanding of the item. Finally, the adapted version of the SDSCA measure included 7 items from three dimensions, and all

items were measured on an eight-point scale ranging from 0 to 7. Of these, five items were about diet, one item was about exercise, and one item was about self-monitoring blood glucose

(SMBG). If a participant exercised three days or more a week, he or she was deemed to have a high level of DSM; otherwise, he or she had a low level of DSM. Similarly, examining FBG twice a

week or more was defined as a high level of SMBG; otherwise, it was a low level. STATISTICAL ANALYSIS To test the selection bias of the sample, Student's t-tests and Pearson’s

Chi-squared tests were performed to compare the differences in sociodemographic characteristics and clinical factors between the follow-up samples and the loss to follow-up samples. Multiple

regression analysis was conducted to explore the correlation between diabetes knowledge and HbA1c levels (T2) after adjusting for sociodemographic characteristics, clinical factors, and

DSM. Then multiple logistic regression analysis was employed to test the stability of the relationship between diabetes knowledge and HbA1c levels. Concurrently, regression diagnosis was

conducted to examine the robustness of models. First, the residual of the two models was predicted to draw a scatter plot. The relationship between diabetes knowledge and HbA1c levels was

linear. Second, eight kinds of indices were calculated to identify singular values. Seventeen singular values were found and were excluded. Third, the dependent variable satisfied a normal

distribution after removing singular values. Additionally, the variance inflation factors (VIFs) of all independent variables were less than 10, which indicated that collinearity did not

exist. Furthermore, the final model passed the White test, which confirmed that there was no heteroscedasticity. Finally, by calculating the cluster robust standard error, the final model

satisfied the assumption of no autocorrelation. Two individuals had missing values on BMI, which we calculated by their weight and height provided in electronic health records. Therefore,

206 participants with complete data were included in the final analyses. All analyses were conducted in Stata 14.0, and a p-value of < 0.05 was considered statistically significant.

ETHICS APPROVAL AND CONSENT TO PARTICIPATE Ethical approval for this study was obtained from the China Ethics Committee of Registering Clinical Trials (ChiECRCT-20180073) on June 8, 2018.

All patients provided informed consent prior to the questionnaire and interview, all personal information was kept confidential, and reporting was made anonymously. All methods were carried

out in accordance with relevant guidelines and regulations. RESULTS PARTICIPANT CHARACTERISTICS As shown in Fig. 1, among the participants who completed the follow-up visits, the average

follow-up time was 319.25 days (SD = 10.90), which was around 10 months. The reasons why 115 participants were loss to follow-up can also be seen in Fig. 1. The sociodemographic

characteristics of the respondents are shown in Table 1. Of 206 respondents, 88.83% were married and 56.8% were farmers. Most of them had a low level of education, with 25.24% being

illiterate, and 36.97% only completing primary school. A majority (83.98%) had an annual household income of no more than 50,000 yuan. CLINICAL CHARACTERISTICS As shown in Table 2, the

average duration of diabetes was 8.11 years (SD = 5.53), with a range of 1–32 years among 206 respondents. Furthermore, 73.3% suffered from diabetes complications, and the top three

complications were cardiovascular disease (72.82%), cerebrovascular disease (0.09%), and diabetic peripheral neuropathy (0.08%). No significant differences were found between the follow-up

samples and loss follow-up samples sample in terms of family history of diabetes, hypoglycemia, the number of complications, duration, BMI, HbA1c levels at baseline, or diabetes knowledge.

RELATIONSHIPS BETWEEN HBA1C LEVELS AND CLINICAL OUTCOMES As shown in Table 3, in terms of diabetes knowledge at baseline, although the mean score of the respondents with HbA1c levels < 7%

(Mean = 10.25, SD = 3.36) was higher than that of the respondents with HbA1c levels ≥ 7% (Mean = 9.83, SD = 3.50), no significant difference was found. Additionally, the mean score for

medication adherence was 7.59 (SD = 1.34), ranging from 0 to 8. For the follow-up sample, 90.78% of them were classified as low-level SMBG, which means that they tested blood glucose less

than twice a week. There were no significant differences between the respondents with HbA1c levels < 7% and respondents with HbA1c levels ≥ 7% in terms of medication adherence, DSM in

diet, and SMBG. As reported in Table 4 and Supplementary Table S2, medication adherence and DSM factors did not influence HbA1c levels significantly in either the multiple linear regression

model or the logistic regression model. DIABETES KNOWLEDGE AS A PREDICTOR OF HBA1C LEVELS AT T2 As shown in Table 4, in Model 1, the inclusion of sex, age, education, marital status,

employment status, and annual household income account for 10.5% of the total variance of HbA1c levels (T2). The combined effect of clinical outcomes at baseline explained an additional

54.9% of the total variance in Model 2. Model 3 indicated that diabetes knowledge was a crucial predictor of HbA1c levels (β = −0.063, _p_ < 0.01), by itself, explaining an additional

1.7% of the total variance. In Model 4 and Model 5, medication adherence and DSM were entered into the multiple regression analyses, and diabetes knowledge was still a significant predictor

factor for HbA1c levels (β = −0.065, _p_ < 0.01; β = −0.062, _p_ < 0.01). Besides, sex (β = −0.669, _p_ < 0.001), age (β = −0.024, _p_ < 0.05), employment status (β = −0.296, _p_

 < 0.05), annual household income (β = 0.473, _p_ < 0.05), and HbA1c levels (T1) (β = 0.828, _p_ < 0.001) significantly influenced the HbA1c levels at T2. To further investigate the

stability of the relationship between diabetes knowledge and HbA1c levels and to explore which factors influenced successful glycemic control, we divided the participants into two groups

according to their HbA1c levels (T2), with a cut-off point of HbA1c levels less than 7%46. If the HbA1c level(T2) was less than 7%, he or she had successful glycemic control, and not vice

versa. Similarly, the covariates were input into the logistic regression model in five steps. Supplementary Table S1 showed that sex, marital status, employment status, HbA1c levels(T1), and

diabetes knowledge significantly influenced HbA1c levels(T2). Female respondents were more likely to control glycemia successfully. The married respondents had higher risks of unsuccessful

glycemic control than single respondents. Compared with people engaged in other jobs, respondents who were farmers were more likely to control glycemia successfully. Apparently, in the

multiple logistic regression model, those respondents who had a higher score of diabetes knowledge would have a greater chance of controlling glycemia successfully. DISCUSSION In this study,

we investigated the correlation between diabetes knowledge and HbA1c levels in people with T2DM based on tracking data in rural China. We found that diabetes knowledge could predict HbA1c

levels before and after adjusting for sociodemographic, clinical, and behavioral variables. Furthermore, multiple logistic regression analysis confirmed the results. It was consistent with

the results of a study also conducted in Jiangsu Province, which found that improving diabetes knowledge helps lower FBG levels after a one-year educational intervention47. The results of

this study may suggest that improving diabetes knowledge leads to a decrease in HbA1c levels. The correlation can be explained by knowledge, attitude, and practices (KAP), which has been

applied to health education practice since the 1960s. For people with T2DM, receiving ongoing diabetes health education can improve their understanding of diabetes and help them establish an

active attitude toward treatments. Patients’ active attitudes may enable them to change their DSM behaviors and further influence the HbA1c levels. However, the coefficient of diabetes

knowledge may not be very high in the multiple linear regression model. Reviewing previous studies, a study estimated that every time the patients answered one more question, the HbA1c level

decreased by 0.23948. Another study found that 82% of participants had HbA1c > 7%, which was associated with poor diabetes knowledge. Additionally, a systematic review concluded that

continuous and regular education could result in a mean reduction of 2.02% for HbA1c among Chinese patients49. In contrast, a study conducted in an urban area in China found that there was

no significant difference in the knowledge scores between people with HbA1c < 7% and those with HbA1c ≥ 7%32. Another study revealed that after a two-year educational intervention, there

was no significant difference in FBG levels between treatment and control groups50. These findings were inconsistent, which suggested that the relationship between diabetes knowledge and

glycemic control is worthy of further study. There are two reasons why the coefficient of diabetes knowledge is not very high. On the one hand, as in previous studies51, there is still a

large gap between knowledge and behaviors related to glycemic control, and attitudes or undiscovered factors may play an essential role in the process. On the other hand, several

sociodemographic variables also influenced the HbA1c level significantly in Model 5. First, female patients’ HbA1c levels (T2) were lower than those of males, and female patients were more

likely to successfully control glycemia. It was not consistent with results obtained from other studies52,53,54,55. Some studies found that there was no sex difference in glycemic

control54,55, and other studies concluded that females were less likely to achieve the target HbA1c of < 7%52,53. Although females had better self-care and high levels of adherence53,

depression was more common in females than males, which made it more difficult for women to successfully control glycemia56. These studies were mostly conducted in urban areas; however, the

setting of this study was a rural area. There are many differences between urban and rural areas, such as economic and cultural factors, which may influence the sex differences in glycemic

control. In rural China, females need to do both farm work and housework, while males are mainly busy with farm work and rarely do housework. Thus, the total amount of exercise of females

may be higher than that of males, which increases the possibility of females achieving success in glycemic control. Second, older patients may have lower HbA1c levels since older patients

have more time to focus on their health, while younger patients are busy dealing with work and family. Third, patients who are farming had lower HbA1c levels than patients in other jobs

because farmers perform more physical activities than other jobs. In addition, compared with people whose monthly income is less than 5,000 yuan, people whose monthly income is 5,000–10,000

yuan had lower HbA1c levels, as patients were capable of paying medical bills. Similarly, sex, employment status, and diabetes knowledge significantly influenced HbA1c levels in the logistic

regression model. Furthermore, married respondents had higher risks of unsuccessful glycemic control than single respondents. It seems probable that when a couple has a conflict, the DSM

behavior of one of them will worsen57. Therefore, it seemed that single patients were more likely to achieve a target HbA1c of < 7%. Notably, as reported in Table 1, the people with T2DM

had poor diabetes knowledge in rural China. This was because they had a low education level, and some of them were even illiterate. In addition, the patients’ mean age was older than 60 

years old, which was related to poor diabetes knowledge, as reported by a qualitative study58. As recent research reported, patients’ low level of diabetes knowledge is an objective

phenomenon in rural China59. Our finding is in line with a study in Thailand60, which found that people with T2DM also had poor diabetes knowledge. Based on the facts of poor diabetes

knowledge, improving diabetes knowledge levels may enable patients to realize the severity of T2DM and promote behavior change. In addition, we found that medication adherence and DSM

factors did not influence HbA1c levels significantly in either the multiple linear regression or logistic regression model. As reported in Table 3, most participants had poor medication

adherence and a low level of DSM due to a lack of diabetes knowledge. It is noted that SMBG was not associated with HbA1c levels (Supplementary Table S4) in this study, which was

inconsistent with the meta-analysis research61. Actually, the relationship between SMBG and HbA1c levels remains unclear. A recent randomized trial found there were no clinically or

statistically significant differences at 1 year in glycemic control between patients who performed SMBG compared with those who did not perform SMBG62. Theoretically, what is important is

the patient’s behavior change based on the results of SMBG that could influence glycemic control, rather than SMBG itself. Therefore, the relationship between these two variables and the

potential mechanism should be explored in the future. There are several limitations to the current study. First, only 64.17% of participants returned for the second measurement of HbA1c.

Although more men declined the second visit (Table 1), no significant difference was found between follow-up men and loss to follow-up men in terms of diabetes knowledge, and neither did

women (Supplementary Table S3). Therefore, the follow-up samples were unbiased and loss to follow-up did not affect the stability of the relationship between diabetes knowledge and HbA1c

levels. Second, the current study relies on a self-report measure of medication adherence and DSM, social desirability bias and recall bias may still exist. More objective measurements of

DSM should be used in the future. Third, only one district was selected in this study, future work will be extended to other sites so that the universality and differences in the

relationship between diabetes knowledge and HbA1c levels can be tested. Concurrently, this study has significant strengths. First, tracking data were used to explore the correlation between

the independent variable and dependent variable, which made causality more plausible. Second, HbA1c was used to assess patients’ average blood glucose concentrations during the preceding 2–3

 months, which were more stable than others. Third, people with T2DM in rural areas were chosen as the study population, who were in urgent need of improving DSM behaviors but were rarely

concerned, which has practical significance. CONCLUSIONS This study provided longitudinal evidence for the effects of diabetes knowledge on HbA1c levels in patients with low education

levels, which indicated that interventions focusing on diabetes knowledge need to be strengthened in rural China. The acquisition of knowledge has been played down for several decades in

community chronic disease management. The findings presented important evidence, that knowledge acquisition may have an important role, which may have some implications for the policy of

chronic disease management for low- and middle-income countries. Improving diabetes knowledge need to be strengthened for patients with low education level in rural China, which help improve

outcomes and reduce the disease burden. DATA AVAILABILITY The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

ABBREVIATIONS * T2DM: Type 2 diabetes mellitus * HbA1c: Glycated haemoglobin * BMI: Body mass index * IDF: International Diabetes Federation * FBG: Fasting blood glucose * DKN: Original

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https://doi.org/10.1001/jamainternmed.2017.1233 (2017). Article  Google Scholar  Download references ACKNOWLEDGEMENTS Thank you for the cooperation of the officials of Health Commission of

Dafeng District in the process of this study, as well as for the cooperation of those who participated in data collection. FUNDING This study was supported by Discipline Construction Funds

from the School of Social Development and Public Policy of Beijing Normal University [Grant No. 312230014] and National Key Research and Development Program of China [Grant No.

2018YFB2101100]. AUTHOR INFORMATION Author notes * These authors contributed equally: Xiaoying Wang and Bo Tian. AUTHORS AND AFFILIATIONS * School of Social Development and Public Policy,

Center for Behavioral Health, Beijing Normal University, Beijing, China Xiaoying Wang, Bo Tian, Jina Li & Weijun Zhang * National Population Heath Data Center, Chinese Academy of Medical

Sciences and Peking Union Medical College, Beijing, China Shengfa Zhang * School of Public Health, Fudan University, Shanghai, China Jinsui Zhang * Yancheng Dafeng People’s Hospital,

Yancheng, Jiangsu Province, China Weiping Yang * School of Sociology and Population Studies, Renmin University of China, Beijing, China Weiwei Wang * North China Electric Power University,

Beijing, China Yuchen Wang Authors * Xiaoying Wang View author publications You can also search for this author inPubMed Google Scholar * Bo Tian View author publications You can also search

for this author inPubMed Google Scholar * Shengfa Zhang View author publications You can also search for this author inPubMed Google Scholar * Jinsui Zhang View author publications You can

also search for this author inPubMed Google Scholar * Weiping Yang View author publications You can also search for this author inPubMed Google Scholar * Jina Li View author publications You

can also search for this author inPubMed Google Scholar * Weiwei Wang View author publications You can also search for this author inPubMed Google Scholar * Yuchen Wang View author

publications You can also search for this author inPubMed Google Scholar * Weijun Zhang View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS

W.Z. was involved in the design of this study and revised the manuscript. X.W., B.T., and S.Z. were involved in the design of this study and data collection. X.W. and W.Z. performed the

statistical analysis and wrote the original draft. J.Z., W.W., J.L., W.Y., and Y.W. contributed to the discussion and reviewed the manuscript. In addition, W.Y. provided full support for

data collection. All authors read and approved the final manuscript. CORRESPONDING AUTHOR Correspondence to Weijun Zhang. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no

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