Disrupted circadian rhythms affect cardiovascular health
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Access through your institution Buy or subscribe End-stage heart disease is associated with severe tissue loss and fat wasting, with obesity being a risk factor. However, obese patients have
a higher likelihood of surviving heart failure compared to normal-weight individuals. While the circadian rhythm is closely linked to lipid metabolism, the relationship between the
circadian rhythm, fat loss and heart failure remains unknown. A study in _Scientific Reports_ shows that the disruption of rats’ circadian clock promotes fat loss associated with heart
failure. Injecting rats with monocrotaline induced pulmonary hypertension, leading to heart failure. Animals in the heart failure group with a normal circadian rhythm showed increased
expression of the biological clock central feedback loop protein REV-ERBα in adipose tissue compared to control rats injected with vehicle solution. All heart failure groups showed
significant fat loss after eight weeks of treatment. However, reversing the light cycle or inhibiting the circadian clock protein brain and muscle Arnt-like protein 1 (BMAL1) via lentiviral
methods led to more severe fat loss. Targeting the BMAL1/REV-ERBα circadian rhythmic loop can serve as a future therapy for fat expenditure in heart failure. ORIGINAL REFERENCE: Ma, D. et
al. _Sci. Rep_. 14, 8128 (2024) This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution ADDITIONAL ACCESS OPTIONS: * Log in *
Learn about institutional subscriptions * Read our FAQs * Contact customer support AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Lab Animal http://www.nature.com/laban/ Jorge Ferreira
Authors * Jorge Ferreira View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Jorge Ferreira. RIGHTS AND PERMISSIONS
Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ferreira, J. Disrupted circadian rhythms affect cardiovascular health. _Lab Anim_ 53, 109 (2024).
https://doi.org/10.1038/s41684-024-01371-w Download citation * Published: 03 May 2024 * Issue Date: May 2024 * DOI: https://doi.org/10.1038/s41684-024-01371-w SHARE THIS ARTICLE Anyone you
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