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The contribution of platelets to atherothrombosis is well established. Accumulating genome-wide association studies have revealed several variants of genes encoding molecules along the

nitric oxide (NO)–soluble guanylyl cyclase (sGC)–cyclic guanosine-3′,5′-monophosphate (cGMP) pathway that are associated with increased risk of coronary artery disease; however, the cell

types and functional impact of these risk variants remain poorly understood. Mauersberger et al. now demonstrate that platelet-specific knockout of a transcript encoding sGC increased

atherosclerosis, whereas pharmacological stimulators of sGC reduced lesions via a paracrine effect of angiopoietin-1 on endothelial cell–leukocyte interactions. Access through your

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476–489 (2017). Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS Supported by the US National Institutes of Health (HL115141, HL134849, HL148207, HL148355, HL153356 to

M.W.F.) and the American Heart Association (18SFRN33900144 and 20SFRN35200163 to M.W.F.). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine, Cardiovascular Division,

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA Anurag Jamaiyar, Jingshu Chen & Mark W. Feinberg Authors * Anurag Jamaiyar View author publications You can also

search for this author inPubMed Google Scholar * Jingshu Chen View author publications You can also search for this author inPubMed Google Scholar * Mark W. Feinberg View author publications

You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Mark W. Feinberg. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing

interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jamaiyar, A., Chen, J. & Feinberg, M.W. Soluble guanylyl cyclase in platelets keeps

atherosclerosis at bay. _Nat Cardiovasc Res_ 1, 1124–1126 (2022). https://doi.org/10.1038/s44161-022-00188-5 Download citation * Published: 12 December 2022 * Issue Date: December 2022 *

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