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Increasing evidence suggests that IGFBP7 may be an accurate biomarker for heart failure. A new study shows that beyond its diagnostic value, IGFBP7 may drive the detrimental effects of

pressure overload in mice by a mechanism that, at least in part, involves the regulation of senescence by an IGF-1R–IR–FOXO3a signaling cascade. Access through your institution Buy or

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ACKNOWLEDGEMENTS This work was supported by FONDAP grant 15130011 (J.R., S.L.) and FONDECYT 11181000 (J.R.) and 1200490 (S.L.). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Advanced Center

for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile Jaime A. Riquelme & Sergio Lavandero *

Interuniversity Center for Healthy Aging, Santiago, Chile Jaime A. Riquelme * Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas,

TX, USA Sergio Lavandero Authors * Jaime A. Riquelme View author publications You can also search for this author inPubMed Google Scholar * Sergio Lavandero View author publications You can

also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Sergio Lavandero. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing

interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Riquelme, J.A., Lavandero, S. IGFBP7 on the road to heart failure: driver or passenger?. _Nat

Cardiovasc Res_ 1, 1121–1123 (2022). https://doi.org/10.1038/s44161-022-00189-4 Download citation * Published: 22 December 2022 * Issue Date: December 2022 * DOI:

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