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Access through your institution Buy or subscribe Nucleic acid therapeutics and preventives, for example, mRNA vaccines, require delivery by nanoparticles to protect nucleic acids and to

allow their cellular update. For example, lipid nanoparticles have enabled the systemic administration of COVID-19 mRNA vaccines. However, the treatment of respiratory virus infections would

greatly benefit from nucleic acid administration directly into the lungs by inhalation. Lung delivery of nucleic acids could further improve the treatment of other pulmonary pathogens and

diseases, such as influenza and cystic fibrosis. Now, writing in _Nature Materials_, Philip J. Santangelo and team identified a polymeric nanoparticle, based on a poly-β-amino-thio-ester,

that can be inhaled to deliver nucleic acids into the lungs of various animal species, regardless of cargo size and complexity. As an alternative to lipid nanoparticles, Santangelo and

colleagues have explored polymeric nanoparticles for lung delivery. The team has previously demonstrated that poly-β-amino-esters (PBAEs) are particularly suited to inhalable delivery of

nucleic acids. Building on this work, they now used a combinatorial synthesis strategy with a nebulizer-based particle screening system to assess 166 PBAEs and PBAE-containing formulations

in mice. “We developed sensitive reporter mRNAs and a nose-only delivery system that allowed us to rapidly screen many polymer chemistries, because we could use very small amounts of mRNA

and polymer for testing,“ explains Santangelo. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal

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customer support REFERENCES ORIGINAL ARTICLE * Rotolo, L. et al. Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung. _Nat. Mater._

https://doi.org/10.1038/s41563-022-01404-0 (2022) Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Bioengineering

https://www.nature.com/natrevbioeng/ Christine-Maria Horejs Authors * Christine-Maria Horejs View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHOR Correspondence to Christine-Maria Horejs. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Horejs, CM. Inhalable polymer delivers RNA

to the lungs. _Nat Rev Bioeng_ 1, 4 (2023). https://doi.org/10.1038/s44222-022-00018-0 Download citation * Published: 19 January 2023 * Issue Date: January 2023 * DOI:

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