Nature catalysis - domino cyclizations
- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:
DOMINO CYCLIZATIONS Electrophilic halocyclizations of olefins are an important class of transformations that can afford various useful halogenated cyclic molecules. In particular, the domino
asymmetric electrophilic halocyclization is viable for synthesis of polycyclic pharmaceutical compounds. However, it remains limited to the generation of fused rings. Now, Yeung et al.
demonstrate the catalytic enantioselective domino halocyclization and spiroketalization to give halo-spiroketals. Mechanistic studies reveal that the reaction is likely to proceed via a
double dynamic kinetic resolution mechanism. See Zheng et al. Image: Tianyu Zheng, The Chinese University of Hong Kong. Cover Design: Valentina Monaco.