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Access through your institution Buy or subscribe LIPOPROTEIN GENOTYPE AND CONSERVED PATHWAY FOR EXCEPTIONAL LONGEVITY IN HUMANS. Atzmon, G. _et al_. _PLoS Biol._ 4, e113 (2006) This study

took advantage of the limited genetic diversity among Ashkenazi Jews to identify a variant that might influence human lifespan. The authors genotyped offspring of 213 centenarians and an

age-matched control group for variants in genes that have potential roles in cardiovascular disease. An allele of the apolipoprotein C3 (_APOC3_) gene, which encodes a protein that increases

levels of harmful cholesterol, showed an association with parental longevity. Decreased APOC3 protein levels among carriers confirmed the variant as having a functional effect. This is a

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THIS ARTICLE CITE THIS ARTICLE In Brief. _Nat Rev Genet_ 7, 332 (2006). https://doi.org/10.1038/nrg1861 Download citation * Issue Date: May 2006 * DOI: https://doi.org/10.1038/nrg1861 SHARE

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