
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression
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Contraction of the hair follicle-lining dermal sheath smooth muscle generates the forces necessary for the tissue remodelling that takes place during the regression phase of the hair growth
cycle. This study reveals that endothelin signalling — from epithelial progenitors at the follicle bottleneck region to its neighbouring dermal sheath — is the main contraction-activating
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taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Lin, X., Zhu,
L. & Je, J. Morphogenesis, growth cycle and molecular regulation of hair follicles. _Front. Cell Dev. Biol._ 10, 899095 (2022). A RECENT REVIEW THAT PROVIDES AN INTRODUCTORY OVERVIEW OF
HAIR FOLLICLE DEVELOPMENT, THE HAIR GROWTH CYCLE AND THEIR MOLECULAR REGULATION. Article PubMed PubMed Central Google Scholar * Heitman, N. et al. Dermal sheath contraction powers stem
cell niche relocation during hair cycle regression. _Science_ 367, 161–166 (2020). THIS PAPER IDENTIFIES THE DERMAL SHEATH AS A SMOOTH MUSCLE THAT CONTRACTS TO DRIVE HAIR FOLLICLE REGRESSION
AND REUNITE NICHE AND STEM CELLS FOR HAIR REGROWTH. Article CAS PubMed Google Scholar * Martino, P. A., Heitman, N. & Rendl, M. The dermal sheath: an emerging component of the hair
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STEM-CELL NICHE, AND EXAMINES POTENTIAL THERAPEUTIC APPLICATIONS IN HAIR REGENERATION AND WOUND HEALING. Article PubMed Google Scholar * Barton, M. & Yanagisawa, M. Endothelin: 30
years from discovery to therapy. _Hypertension_ 74, 1232–1265 (2019). THIS REVIEW SUMMARIZES PIVOTAL ENDOTHELIN SIGNALLING STUDIES, FROM THE DISCOVERY OF ENDOTHELIN TO ITS ROLE IN GENETICS,
PHYSIOLOGY AND DISEASE. Article CAS PubMed Google Scholar * Fuchs, E. & Blau, H. M. Tissue stem cells: architects of their niches. _Cell Stem Cell_ 27, 532–556 (2020). A REVIEW
ARTICLE THAT DISCUSSES HOW STEM CELLS MEDIATE TISSUE RENEWAL IN THE SKIN EPITHELIUM AND SKELETAL MUSCLE. Article CAS PubMed PubMed Central Google Scholar Download references ADDITIONAL
INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: Martino, P. et al.
Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression. _Nat. Cell Biol_. https://doi.org/10.1038/s41556-022-01065-w (2023). RIGHTS AND PERMISSIONS
Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression. _Nat Cell Biol_ 25, 220–221
(2023). https://doi.org/10.1038/s41556-022-01077-6 Download citation * Published: 30 January 2023 * Issue Date: February 2023 * DOI: https://doi.org/10.1038/s41556-022-01077-6 SHARE THIS
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