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ABSTRACT Two groups of human lymphocytes are distinguished on the basis of immune effector functions, membrane markers and _in vitro_ mitogen reactivity. Thymus-derived (T) lymphocytes

mediate cellular immunity either directly or by secreting pharmacologically active lymphokines1, and are implicated in facilitating antibody responses2. In contrast, bone marrow-derived (B)

lymphocytes are thought to produce only antibodies. Studies in the guinea pig, however, indicate that, appropriately stimulated, B cells can produce macrophage migration inhibitory factor

(MIF)3. We have now found that the erythrocyte–antibody (19S)–complement (EAC) rosetting method, used to obtain pure human peripheral blood B cells, activates these B cells to produce

mononuclear cell chemotactic (CTX) and mitogenic (MF) lymphokines. Furthermore, we have investigated the mechanism of B cell activation by EAC and the effects of mitogenic lymphokines on

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FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS DETECTION OF CLCF1 PROTEIN EXPRESSION BY FLOW CYTOMETRY Article Open access 10 June 2024 RECREATION OF AN

ANTIGEN-DRIVEN GERMINAL CENTER IN VITRO BY PROVIDING B CELLS WITH PHAGOCYTIC ANTIGEN Article Open access 20 April 2023 A BIPHENOTYPIC LYMPHOCYTE SUBSET DISPLAYS BOTH T- AND B-CELL

FUNCTIONALITIES Article Open access 05 January 2024 REFERENCES * Good, R. A., _Cell. Immun._, 3, 1 (1972). Article  Google Scholar  * Anderson, J., Möller, G., and Sjöberg, O., _Eur. J.

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Texas Dental Science Institute, PO Box 20068, Houston, Texas, 77025 AUTHORS AND AFFILIATIONS * Laboratory of Microbiology and Immunology, National Institute of Dental Research, National

Institutes of Health, Bethesda, Maryland, 20014 B. F. MACKLER, L. C. ALTMAN, D. L. ROSENSTREICH & J. J. OPPENHEIM Authors * B. F. MACKLER View author publications You can also search for

this author inPubMed Google Scholar * L. C. ALTMAN View author publications You can also search for this author inPubMed Google Scholar * D. L. ROSENSTREICH View author publications You can

also search for this author inPubMed Google Scholar * J. J. OPPENHEIM View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE MACKLER, B., ALTMAN, L., ROSENSTREICH, D. _et al._ Induction of lymphokine production by EAC and of blastogenesis by soluble mitogens

during human B-cell activation. _Nature_ 249, 834–837 (1974). https://doi.org/10.1038/249834a0 Download citation * Received: 23 January 1974 * Revised: 19 April 1974 * Issue Date: 28 June

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